Reactome | CASP14 cleaves filaggrin

CASP14 cleaves filaggrin

Stable Identifier

R-HSA-6814387

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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In fully cornified cells, filaggrin is degraded into free amino acids. This high concentration of hydrophillic amino acids is essential for water retention and contributes to the osmolarity, and consequently the flexibility of the cornified layer (Candi et al. 2005). Filaggrin monomers are a direct target for cleavage by the aspartate-specific protease caspase 14 (Denecker et al. 2007, 2008, Hoste et al. 2011, Eckhart & Tschachler 2011). Proteases able to process profilaggrin into fillagrin in vitro include microbial ST14 (Profillagrin endopeptidase 1, PEP1), CAPN1 (mu-calpain), furin, PACE4 and matriptase MT-SP1 (Reising et al. 1995, Yamazaki et al. 1997, Pearton et al. 2001, List et al. 2003, Candi et al. 2005), but these proteases do not appear to have a role in the degradation of filaggrin that occurs at a late stage in keratinization.

Literature References

PubMed ID	Title	Journal	Year
21654840	Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin Hoste, E, Kemperman, P, Devos, M, Denecker, G, Kezic, S, Yau, N, Gilbert, B, Lippens, S, De Groote, P, Roelandt, R, Van Damme, P, Gevaert, K, Presland, RB, Takahara, H, Puppels, G, Caspers, P, Vandenabeele, P, Declercq, W	J. Invest. Dermatol.	2011
17515931	Caspase-14 protects against epidermal UVB photodamage and water loss Denecker, G, Hoste, E, Gilbert, B, Hochepied, T, Ovaere, P, Lippens, S, Van den Broecke, C, Van Damme, P, D'Herde, K, Hachem, JP, Borgonie, G, Presland, RB, Schoonjans, L, Libert, C, Vandekerckhove, J, Gevaert, K, Vandenabeele, P, Declercq, W	Nat. Cell Biol.	2007