Reactome | CASP14 cleaves filaggrin

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10418887] cysteine-type endopeptidase activity of CASP14 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10418889
displayName	CASP14 cleaves filaggrin
eventOf	[Pathway:R-BTA-6809371] Formation of the cornified envelope - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6814387] CASP14 cleaves filaggrin - Homo sapiens
input	[Complex:R-BTA-6814275] Late cornified envelope [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CASP14 cleaves filaggrin
output	[Complex:R-BTA-6814763] Mature cornified envelope [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6814387
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-6809371] Formation of the cornified envelope
(inferredTo)	[Reaction:R-HSA-6814387] CASP14 cleaves filaggrin

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