Reactome | NCEH1 hydrolyzes cholesterol esters

Schema > Reaction > Entries

NCEH1 hydrolyzes cholesterol esters Show undefined attributes

authored	[InstanceEdit:6813722] D'Eustachio, Peter, 2015-11-23
catalystActivity	[CatalystActivity:6813682] sterol ester esterase activity of NCEH1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:13977] lipid droplet [Compartment:13946] transport vesicle membrane
created	[InstanceEdit:6813722] D'Eustachio, Peter, 2015-11-23
dbId	6813720
displayName	NCEH1 hydrolyzes cholesterol esters
edited	[InstanceEdit:6813722] D'Eustachio, Peter, 2015-11-23
eventOf	[Pathway:R-HSA-8964038] LDL clearance - Homo sapiens
followingEvent	[Reaction:R-HSA-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-163579] CHEST [lipid droplet] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6813679] Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence [LiteratureReference:6813687] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages [LiteratureReference:6813673] Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages [LiteratureReference:6813674] Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	NCEH1 hydrolyzes cholesterol esters
orthologousEvent	[Reaction:R-SPO-6813720] NCEH1 hydrolyzes cholesterol esters - Schizosaccharomyces pombe [Reaction:R-DDI-6813720] NCEH1 hydrolyzes cholesterol esters - Dictyostelium discoideum [Reaction:R-CEL-6813720] NCEH1 hydrolyzes cholesterol esters - Caenorhabditis elegans [Reaction:R-GGA-6813720] NCEH1 hydrolyzes cholesterol esters - Gallus gallus [Reaction:R-DRE-6813720] NCEH1 hydrolyzes cholesterol esters - Danio rerio [Reaction:R-SSC-6813720] NCEH1 hydrolyzes cholesterol esters - Sus scrofa [Reaction:R-BTA-6813720] NCEH1 hydrolyzes cholesterol esters - Bos taurus [Reaction:R-CFA-6813720] NCEH1 hydrolyzes cholesterol esters - Canis familiaris [Reaction:R-RNO-6813720] NCEH1 hydrolyzes cholesterol esters - Rattus norvegicus [Reaction:R-MMU-6813720] NCEH1 hydrolyzes cholesterol esters - Mus musculus
output	[SimpleEntity:R-ALL-216762] CHOL [transport vesicle membrane] [SimpleEntity:R-ALL-8876730] LCFA(-) [cytosol]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8847445] Jassal, Bijay, 2015-11-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6813720
summation	[Summation:6813721] NCEH1 (neutral cholesterol ester hydrolase) hydrolyzes chole...
updateTrackers	[UpdateTracker:9782957] Update Tracker - [Reaction:6813720] NCEH1 hydrolyzes cholesterol esters - v58:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782957] Update Tracker - [Reaction:6813720] NCEH1 hydrolyzes cholesterol esters - v58:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-8964038] LDL clearance
(precedingEvent)	[Reaction:R-HSA-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane

Cite Us!