Reactome | NCEH1 hydrolyzes cholesterol esters

Schema > Reaction > Entries

NCEH1 hydrolyzes cholesterol esters Show undefined attributes

catalystActivity	[CatalystActivity:10628528] sterol ester esterase activity of NCEH1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:13977] lipid droplet [Compartment:13946] transport vesicle membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10628530
displayName	NCEH1 hydrolyzes cholesterol esters
eventOf	[Pathway:R-DRE-8964038] LDL clearance - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - Danio rerio
inferredFrom	[Reaction:R-HSA-6813720] NCEH1 hydrolyzes cholesterol esters - Homo sapiens
input	[SimpleEntity:R-ALL-163579] CHEST [lipid droplet] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NCEH1 hydrolyzes cholesterol esters
output	[SimpleEntity:R-ALL-216762] CHOL [transport vesicle membrane] [SimpleEntity:R-ALL-8876730] LCFA(-) [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6813720
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8964038] LDL clearance
(precedingEvent)	[Reaction:R-DRE-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane
(inferredTo)	[Reaction:R-HSA-6813720] NCEH1 hydrolyzes cholesterol esters