NCEH1 hydrolyzes cholesterol esters

Stable Identifier
R-HSA-6813720
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NCEH1 (neutral cholesterol ester hydrolase) hydrolyzes cholesterol esters to form cholesterol (CHOL) and free fatty acids (LCFA). In both humans (Igarashi et al. 2010a) and mice (Igarashi et al. 2010b, Okazaki et al. 2008, Sakai et al. 2014 ) NCEH1 associated with the endoplasmic reticulum membrane appears to play a major role in cholesterol ester hydrolysis in macrophages. Free CHOL is transported via transport vesicles and can be used for cellular functions or removed from the cell by ABCA1 to create new HDL particles.

Literature References
PubMed ID Title Journal Year
24868095 Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages

Sakai, K, Igarashi, M, Yamamuro, D, Ohshiro, T, Nagashima, S, Takahashi, M, Enkhtuvshin, B, Sekiya, M, Okazaki, H, Osuga, J, Ishibashi, S

J. Lipid Res. 2014
18782767 Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages

Okazaki, H, Igarashi, M, Nishi, M, Sekiya, M, Tajima, M, Takase, S, Takanashi, M, Ohta, K, Tamura, Y, Okazaki, S, Yahagi, N, Ohashi, K, Amemiya-Kudo, M, Nakagawa, Y, Nagai, R, Kadowaki, T, Osuga, J, Ishibashi, S

J. Biol. Chem. 2008
19592704 Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence

Igarashi, M, Osuga, J, Isshiki, M, Sekiya, M, Okazaki, H, Takase, S, Takanashi, M, Ohta, K, Kumagai, M, Nishi, M, Fujita, T, Nagai, R, Kadowaki, T, Ishibashi, S

J. Lipid Res. 2010
20947831 The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages

Igarashi, M, Osuga, J, Uozaki, H, Sekiya, M, Nagashima, S, Takahashi, M, Takase, S, Takanashi, M, Li, Y, Ohta, K, Kumagai, M, Nishi, M, Hosokawa, M, Fledelius, C, Jacobsen, P, Yagyu, H, Fukayama, M, Nagai, R, Kadowaki, T, Ohashi, K, Ishibashi, S

Circ. Res. 2010
Participants
Participates
Catalyst Activity

sterol esterase activity of NCEH1 [endoplasmic reticulum membrane]

Orthologous Events
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