NCEH1 (neutral cholesterol ester hydrolase) hydrolyzes chole...

created [InstanceEdit:6813722] D'Eustachio, Peter, 2015-11-23
dbId 6813721
displayName NCEH1 (neutral cholesterol ester hydrolase) hydrolyzes chole...
modified [InstanceEdit:8876874] Jassal, Bijay, 2016-06-17
schemaClass Summation
text NCEH1 (neutral cholesterol ester hydrolase) hydrolyzes cholesterol esters to form cholesterol (CHOL) and free fatty acids (LCFA). In both humans (Igarashi et al. 2010a) and mice (Igarashi et al. 2010b, Okazaki et al. 2008, Sakai et al. 2014 ) NCEH1 associated with the endoplasmic reticulum membrane appears to play a major role in cholesterol ester hydrolysis in macrophages. Free CHOL is transported via transport vesicles and can be used for cellular functions or removed from the cell by ABCA1 to create new HDL particles.
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