Reactome | MTMR12 binds MTM1

MTMR12 binds MTM1

Stable Identifier

R-HSA-6809680

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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MTM1 forms a complex with MTMR12 (3 PAP), an enzymatically inactive myotubularin family member. MTMR12 promotes MTM1 recruitment to cytosolic vesicular structures, presumably early or late endosomes. Complex formation stabilizes both MTM1 and MTMR12 proteins (Caldwell et al. 1991, Nandurkar et al. 2003, Gupta et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
1655747	Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate Caldwell, KK, Lips, DL, Bansal, VS, Majerus, PW	J. Biol. Chem.	1991
23818870	Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish Gupta, VA, Hnia, K, Smith, LL, Gundry, SR, McIntire, JE, Shimazu, J, Bass, JR, Talbot, EA, Amoasii, L, Goldman, NE, Laporte, J, Beggs, AH	PLoS Genet.	2013
12847286	Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP Nandurkar, HH, Layton, M, Laporte, J, Selan, C, Corcoran, L, Caldwell, KK, Mochizuki, Y, Majerus, PW, Mitchell, CA	Proc. Natl. Acad. Sci. U.S.A.	2003