MTMR12 binds MTM1

Stable Identifier
R-HSA-6809680
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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MTMR12 binds MTM1
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MTM1 forms a complex with MTMR12 (3 PAP), an enzymatically inactive myotubularin family member. MTMR12 promotes MTM1 recruitment to cytosolic vesicular structures, presumably early or late endosomes. Complex formation stabilizes both MTM1 and MTMR12 proteins (Caldwell et al. 1991, Nandurkar et al. 2003, Gupta et al. 2013).

Literature References
PubMed ID Title Journal Year
1655747 Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate

Caldwell, KK, Lips, DL, Bansal, VS, Majerus, PW

J. Biol. Chem. 1991
23818870 Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish

Gupta, VA, Hnia, K, Smith, LL, Gundry, SR, McIntire, JE, Shimazu, J, Bass, JR, Talbot, EA, Amoasii, L, Goldman, NE, Laporte, J, Beggs, AH

PLoS Genet. 2013
12847286 Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP

Nandurkar, HH, Layton, M, Laporte, J, Selan, C, Corcoran, L, Caldwell, KK, Mochizuki, Y, Majerus, PW, Mitchell, CA

Proc. Natl. Acad. Sci. U.S.A. 2003
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Orthologous Events
MTMR12 binds MTM1 (Bos taurus)
MTMR12 binds MTM1 (Caenorhabditis elegans)
MTMR12 binds MTM1 (Canis familiaris)
MTMR12 binds MTM1 (Danio rerio)
MTMR12 binds MTM1 (Dictyostelium discoideum)
MTMR12 binds MTM1 (Drosophila melanogaster)
MTMR12 binds MTM1 (Gallus gallus)
MTMR12 binds MTM1 (Mus musculus)
MTMR12 binds MTM1 (Rattus norvegicus)
MTMR12 binds MTM1 (Saccharomyces cerevisiae)
MTMR12 binds MTM1 (Schizosaccharomyces pombe)
MTMR12 binds MTM1 (Sus scrofa)
MTMR12 binds MTM1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-11-13)
Reviewed
Rush, MG  (2017-01-10)
Created
Orlic-Milacic, M  (2015-11-12)
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