Reactome | IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]

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IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:9006665] transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-HSA-8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated - Homo sapiens
created	[InstanceEdit:6809137] Garapati, Phani Vijay, 2015-11-09
dbId	6809138
displayName	IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
hasComponent	[Complex:R-HSA-8950039] IL12RB2:JAK2 [plasma membrane] [Complex:R-HSA-622267] IL35 [extracellular region] [Complex:R-HSA-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Mus musculus [Complex:R-RNO-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Canis familiaris [Complex:R-BTA-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Bos taurus [Complex:R-SSC-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Sus scrofa [Complex:R-XTR-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Gallus gallus
literatureReference	[LiteratureReference:8949808] Interleukin-35 induces regulatory B cells that suppress autoimmune disease
maxDepth	4
modified	[InstanceEdit:8985450] Varusai, Thawfeek, 2017-04-16
name	IL35:IL6ST:JAK1:IL12RB2:JAK2 IL35:IL12RB2:JAK2:gp130:JAK2
producedByEvent	[BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6809138
summation	[Summation:8950087] Interleukin-35(IL-35) ,a heterodimer composed by Interleukin...
updateTrackers	[UpdateTracker:9896360] Update Tracker - [Complex:6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - v60:[addLiteratureReference, addSummation, add_removeHasComponent, modifyName, updateContainedComponent] [UpdateTracker:9896916] Update Tracker - [Complex:6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - v61:[add_removeHasComponent, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9896360] Update Tracker - [Complex:6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - v60:[addLiteratureReference, addSummation, add_removeHasComponent, modifyName, updateContainedComponent] [UpdateTracker:9896916] Update Tracker - [Complex:6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - v61:[add_removeHasComponent, modifyName]
(output)	[BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor
(input)	[BlackBoxEvent:R-HSA-8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
(physicalEntity)	[CatalystActivity:9006665] transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]

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