Reactome | IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10205473] transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-RNO-8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10195619
displayName	IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
hasComponent	[Complex:R-RNO-8950039] IL12RB2:JAK2 [plasma membrane] [Complex:R-RNO-622267] IL35 [extracellular region] [Complex:R-RNO-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Homo sapiens
maxDepth	4
name	IL35:IL6ST:JAK1:IL12RB2:JAK2
producedByEvent	[BlackBoxEvent:R-RNO-6809140] IL35 binds IL-12RB2:IL6ST receptor - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6809138
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-RNO-8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
(physicalEntity)	[CatalystActivity:10205473] transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
(output)	[BlackBoxEvent:R-RNO-6809140] IL35 binds IL-12RB2:IL6ST receptor
(inferredTo)	[Complex:R-HSA-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]

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