IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]

Stable Identifier
R-HSA-6809138
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL35:IL12RB2:JAK2:gp130:JAK2
Locations in the PathwayBrowser
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General

Interleukin-35(IL-35) ,a heterodimer composed by Interleukin-12 subunit beta and Interleukin-27 subunit alpha, signals through IL-12R beta2(IL12RB2) and Interleukin-27 receptor alpha(IL-27RA) in B cells, activating signal transducer and activator of transcription 1(STAT1) and signal transducer and activator of transcription 3(STAT3).

Literature References
PubMed ID Title Journal Year
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Kim, SH, Wingfield, PT, Mahdi, RM, Dambuza, IM, Yu, CR, Wang, RX, Sergeev, YV, Egwuagu, CE, Dolinska, MB

Nat. Med. 2014
Participants
components
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as an output of
as an input of
Inferred To
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Bos taurus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Danio rerio)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Sus scrofa)
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