IL35:IL6ST:JAK1:IL12RB2:JAK2

Stable Identifier
R-HSA-6809138
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
IL35:IL12RB2:JAK2:gp130:JAK2
Locations in the PathwayBrowser
Summation

Interleukin-35(IL-35) ,a heterodimer composed by Interleukin-12 subunit beta and Interleukin-27 subunit alpha, signals through IL-12R beta2(IL12RB2) and Interleukin-27 receptor alpha(IL-27RA) in B cells, activating signal transducer and activator of transcription 1(STAT1) and signal transducer and activator of transcription 3(STAT3).

Literature References
PubMed ID Title Journal Year
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Wang, RX, Yu, CR, Dambuza, IM, Mahdi, RM, Dolinska, MB, Sergeev, YV, Wingfield, PT, Kim, SH, Egwuagu, CE

Nat. Med. 2014
Participants
Participant Of
Inferred To