IL35:IL6ST:JAK1:IL12RB2:JAK2

Stable Identifier
R-HSA-6809138
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
IL35:IL12RB2:JAK2:gp130:JAK2
Locations in the PathwayBrowser
Summation

Interleukin-35(IL-35) ,a heterodimer composed by Interleukin-12 subunit beta and Interleukin-27 subunit alpha, signals through IL-12R beta2(IL12RB2) and Interleukin-27 receptor alpha(IL-27RA) in B cells, activating signal transducer and activator of transcription 1(STAT1) and signal transducer and activator of transcription 3(STAT3).

Literature References
PubMed ID Title Journal Year
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease Nat. Med. 2014
Participants
Participant Of
Inferred To