Reactome | IL35 [extracellular region]

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IL35 [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-8985441] IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-8983525] IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-8985392] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor - Homo sapiens [BlackBoxEvent:R-HSA-8984001] IL35 binds IL27RA:IL12RB2 receptor - Homo sapiens [BlackBoxEvent:R-HSA-8983518] IL35 binds IL6ST:IL6ST receptor - Homo sapiens [BlackBoxEvent:R-HSA-8983519] IL35 binds IL12RB2:IL12RB2 receptor - Homo sapiens
created	[InstanceEdit:622266] Jupe, S, 2010-04-22
dbId	622267
displayName	IL35 [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-HSA-448418] EBI3 [extracellular region] [EntityWithAccessionedSequence:R-HSA-447212] IL12A [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-622267] IL35 [extracellular region] - Mus musculus [Complex:R-RNO-622267] IL35 [extracellular region] - Rattus norvegicus [Complex:R-CFA-622267] IL35 [extracellular region] - Canis familiaris [Complex:R-BTA-622267] IL35 [extracellular region] - Bos taurus [Complex:R-SSC-622267] IL35 [extracellular region] - Sus scrofa [Complex:R-XTR-622267] IL35 [extracellular region] - Xenopus tropicalis [Complex:R-GGA-622267] IL35 [extracellular region] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:8949818] Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin [LiteratureReference:8949825] Low Serum Levels of Interleukin 35 in Patients with Rheumatoid Arthritis
maxDepth	2
modified	[InstanceEdit:8983874] Varusai, Thawfeek, 2017-03-30
name	IL35 Interleukin-35 IL12A:EBI3
producedByEvent	[BlackBoxEvent:R-HSA-448627] Interleukin-35 translocates from the ER lumen to the extracellular region - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-622267
summation	[Summation:8949826] Interleukin-35 can be secreted(PMID: 9342359) and be detecte...
updateTrackers	[UpdateTracker:9896824] Update Tracker - [Complex:622267] IL35 [extracellular region] - v60:[addLiteratureReference, addName, addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9896824] Update Tracker - [Complex:622267] IL35 [extracellular region] - v60:[addLiteratureReference, addName, addSummation]
(input)	[BlackBoxEvent:R-HSA-8983518] IL35 binds IL6ST:IL6ST receptor [BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor [BlackBoxEvent:R-HSA-8983519] IL35 binds IL12RB2:IL12RB2 receptor [BlackBoxEvent:R-HSA-8984001] IL35 binds IL27RA:IL12RB2 receptor
(hasComponent)	[Complex:R-HSA-8985441] IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] [Complex:R-HSA-8983525] IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] [Complex:R-HSA-8983843] IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] [Complex:R-HSA-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] [Complex:R-HSA-8950255] IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] [Complex:R-HSA-8983520] IL35:(IL12RB2:JAK2 dimer) [plasma membrane] [Complex:R-HSA-8983873] IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] [Complex:R-HSA-8951178] IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] [Complex:R-HSA-8985392] IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] [Complex:R-HSA-8983989] IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane]
(output)	[BlackBoxEvent:R-HSA-448627] Interleukin-35 translocates from the ER lumen to the extracellular region

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