Reactome | MET Receptor Activation

Schema > Pathway > Entries

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558461
displayName	MET Receptor Activation
eventOf	[Pathway:R-SSC-6806834] Signaling by MET - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-6800200] HPN heterodimer cleaves pro-HGF to form HGF dimer - Sus scrofa [Reaction:R-SSC-6800299] HGFAC cleaves pro-HGF to form HGF dimer - Sus scrofa [Reaction:R-SSC-6800298] HGF dimer binds MET - Sus scrofa [Reaction:R-SSC-6806957] MET receptor dimerizes - Sus scrofa [Reaction:R-SSC-6806974] MET dimers autophosphorylate - Sus scrofa
inferredFrom	[Pathway:R-HSA-6806942] MET Receptor Activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MET Receptor Activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-6806942
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-6806834] Signaling by MET
(inferredTo)	[Pathway:R-HSA-6806942] MET Receptor Activation