Reactome | p14ARF forms a ternary complex with MDM2 and TP53

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p14ARF forms a ternary complex with MDM2 and TP53 Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6804997] Orlic-Milacic, Marija, 2015-10-16
dbId	6804998
deleted	[Deleted:8932782] Deletion of instance: 3209185
displayName	p14ARF forms a ternary complex with MDM2 and TP53
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-6804996] p14ARF sequesters MDM2 - Homo sapiens
input	[Complex:R-HSA-6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1629813] p14ARF [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3209191] ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p14ARF forms a ternary complex with MDM2 and TP53
output	[Complex:R-HSA-6804999] p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5633460] MDM2 binds TP53 - Homo sapiens [BlackBoxEvent:R-HSA-9645672] p14ARF translocates to the nucleus - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6804998
summation	[Summation:3245956] p14ARF forms a complex with TP53-bound MDM2 by interacting w...
updateTrackers	[UpdateTracker:9777795] Update Tracker - [Reaction:6804998] p14ARF forms a ternary complex with MDM2 and TP53 - v69:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777795] Update Tracker - [Reaction:6804998] p14ARF forms a ternary complex with MDM2 and TP53 - v69:[modifyText]
(replacementInstances)	[Deleted:8932782] Deletion of instance: 3209185
(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-2559585] Oncogene Induced Senescence [Pathway:R-HSA-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-HSA-6804996] p14ARF sequesters MDM2

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