p14ARF forms a ternary complex with MDM2 and TP53

Stable Identifier
R-HSA-6804998
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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p14ARF forms a complex with TP53-bound MDM2 by interacting with the C-terminus of MDM2, while the N-terminus of MDM2 is involved in TP53 (p53) binding. p14ARF cannot associate with TP53 in the absence of MDM2 (Zhang et al. 1998).

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