MDM2 homodimers auto-ubiquitinate

Stable Identifier
R-HSA-6804942
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MDM2 undergoes auto-ubiquitination (Fang et al. 2000). Formation of homodimers may not be necessary for auto-ubiquitination (Cheng et al. 2011).

Literature References
PubMed ID Title Journal Year
10722742 Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Fang, S, Jensen, JP, Ludwig, RL, Vousden, KH, Weissman, AM

J. Biol. Chem. 2000
21986495 Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage

Cheng, Q, Cross, B, Li, B, Chen, L, Li, Z, Chen, J

Mol. Cell. Biol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created