Reactome | MDM2 homodimers auto-ubiquitinate

MDM2 homodimers auto-ubiquitinate

Stable Identifier

R-HSA-6804942

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        MDM2 homodimers auto-ubiquitinate (Homo sapiens)

General

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MDM2 undergoes auto-ubiquitination (Fang et al. 2000). Formation of homodimers may not be necessary for auto-ubiquitination (Cheng et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21986495	Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage Cheng, Q, Cross, B, Li, B, Chen, L, Li, Z, Chen, J	Mol. Cell. Biol.	2011
10722742	Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 Fang, S, Jensen, JP, Ludwig, RL, Vousden, KH, Weissman, AM	J. Biol. Chem.	2000