MDM2 homodimers auto-ubiquitinate

Stable Identifier
R-HSA-6804942
Type
Reaction
Species
Homo sapiens
Compartment
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MDM2 undergoes auto-ubiquitination (Fang et al. 2000). Formation of homodimers may not be necessary for auto-ubiquitination (Cheng et al. 2011).

Literature References
PubMed ID Title Journal Year
21986495 Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage

Chen, L, Chen, J, Cheng, Q, Li, B, Cross, B, Li, Z

Mol. Cell. Biol. 2011
10722742 Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Vousden, KH, Weissman, AM, Jensen, JP, Ludwig, RL, Fang, S

J. Biol. Chem. 2000
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer [nucleoplasm]

Orthologous Events
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