Reactome | MDM2 ubiquitinates phosphorylated MDM4

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MDM2 ubiquitinates phosphorylated MDM4 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6804946] ubiquitin protein ligase activity of p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6804721] Orlic-Milacic, Marija, 2015-10-14
dbId	6804724
displayName	MDM2 ubiquitinates phosphorylated MDM4
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-6805022] USP2 binds the heterodimer of MDM2 and MDM4 - Homo sapiens [Reaction:R-HSA-3222072] DAXX binds Ub-MDM2 and USP7 - Homo sapiens
input	[Complex:R-HSA-6804936] p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] 6 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:349453] ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage [LiteratureReference:349458] Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage [LiteratureReference:6804878] HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MDM2 ubiquitinates phosphorylated MDM4
negativePrecedingEvent	[NegativePrecedingEvent:9944349] Proteolytic degradation of ubiquitinated-Cdc25A
orthologousEvent	[Reaction:R-GGA-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Gallus gallus [Reaction:R-DRE-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Danio rerio [Reaction:R-CFA-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Canis familiaris [Reaction:R-RNO-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Rattus norvegicus [Reaction:R-MMU-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Mus musculus
output	[Complex:R-HSA-6804937] PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6804724
summation	[Summation:6804720] Once MDM4 is phosphorylated by ATM and CHEK2 in response to ...

Referrals

(hasEvent)	[Pathway:R-HSA-69541] Stabilization of p53 [Pathway:R-HSA-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-HSA-6805022] USP2 binds the heterodimer of MDM2 and MDM4 [Reaction:R-HSA-3222072] DAXX binds Ub-MDM2 and USP7