Once MDM4 is phosphorylated by ATM and CHEK2 in response to DNA damage, MDM2 ubiquitinates MDM4 and targets it for degradation (Chen et al. 2005, Pereg et al. 2005). The presence of MDM4 stimulates auto-ubiquitination of MDM2 (Linares et al. 2003).
Linares, LK, Scheffner, M, Hengstermann, A, Muller, S, Ciechanover, A
Lane, WS, Chen, L, Pan, Y, Chen, J, Gilkes, DM
Shiloh, Y, Meulmeester, E, Jochemsen, AG, Pereg, Y, Teunisse, AF, Shkedy, D, de Graaf, P, Biton, S, Lehmann, WD, Edelson-Averbukh, M, Salek, M
ubiquitin protein ligase activity of p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm]
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