MDM2 ubiquitinates phosphorylated MDM4

Stable Identifier
Reaction [transition]
Homo sapiens
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Once MDM4 is phosphorylated by ATM and CHEK2 in response to DNA damage, MDM2 ubiquitinates MDM4 and targets it for degradation (Chen et al. 2005, Pereg et al. 2005). The presence of MDM4 stimulates auto-ubiquitination of MDM2 (Linares et al. 2003).

Literature References
PubMed ID Title Journal Year
14507994 HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

Linares, LK, Scheffner, M, Hengstermann, A, Muller, S, Ciechanover, A

Proc. Natl. Acad. Sci. U.S.A. 2003
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Lane, WS, Chen, L, Pan, Y, Chen, J, Gilkes, DM

EMBO J 2005
15788536 Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

Shiloh, Y, Meulmeester, E, Jochemsen, AG, Pereg, Y, Teunisse, AF, Shkedy, D, de Graaf, P, Biton, S, Lehmann, WD, Edelson-Averbukh, M, Salek, M

Proc Natl Acad Sci U S A 2005
Catalyst Activity

ubiquitin protein ligase activity of p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm]

Orthologous Events
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