Reactome | MDM2 ubiquitinates phosphorylated MDM4

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MDM2 ubiquitinates phosphorylated MDM4 Show undefined attributes

catalystActivity	[CatalystActivity:10626353] ubiquitin protein ligase activity of p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10626355
displayName	MDM2 ubiquitinates phosphorylated MDM4
eventOf	[Pathway:R-DRE-69541] Stabilization of p53 - Danio rerio [Pathway:R-DRE-6804757] Regulation of TP53 Degradation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Homo sapiens
input	[Complex:R-DRE-6804936] p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] 6 × [DefinedSet:R-DRE-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MDM2 ubiquitinates phosphorylated MDM4
output	[Complex:R-DRE-6804937] PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6804724
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-69541] Stabilization of p53 [Pathway:R-DRE-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-6804724] MDM2 ubiquitinates phosphorylated MDM4

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