Reactome | capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm]

Schema > Complex > Entries

capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-6803525] FGFR2 IIIb-specific splicing complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-6803522] FGFR2 IIIc-specific splicing complex [nucleoplasm] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-8851710] Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant - Homo sapiens [BlackBoxEvent:R-HSA-6803836] FGFR2b-specific alternative splicing produces FGFR2b transcript - Homo sapiens [BlackBoxEvent:R-HSA-6803838] FGFR2c-specific alternative splicing produces FGFR2c transcript - Homo sapiens [Reaction:R-HSA-6803527] ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression - Homo sapiens [Reaction:R-HSA-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Homo sapiens
created	[InstanceEdit:6803520] Rothfels, Karen, 2015-10-06
dbId	6803524
displayName	capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm]
hasComponent	[Complex:R-HSA-77088] Cap Binding Complex (CBC) [nucleoplasm] [GenomeEncodedEntity:R-HSA-6803521] capped, methylated FGFR2 nascent transcript [nucleoplasm] [Complex:R-HSA-71307] RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Mus musculus [Complex:R-RNO-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Canis familiaris [Complex:R-BTA-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Bos taurus [Complex:R-SSC-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Sus scrofa [Complex:R-XTR-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Gallus gallus [Complex:R-DME-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SCE-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Saccharomyces cerevisiae [Complex:R-PFA-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] - Plasmodium falciparum
isChimeric	false
name	capped, methylated pre-FGFR2 mRNA:CBC complex
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6803524

Referrals

(input)	[BlackBoxEvent:R-HSA-8851710] Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant [BlackBoxEvent:R-HSA-6803836] FGFR2b-specific alternative splicing produces FGFR2b transcript [BlackBoxEvent:R-HSA-6803838] FGFR2c-specific alternative splicing produces FGFR2c transcript [Reaction:R-HSA-6803527] ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression [Reaction:R-HSA-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
(diseaseEntity)	[EntityFunctionalStatus:9630097] gain_of_function of capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm]
(hasComponent)	[Complex:R-HSA-6803525] FGFR2 IIIb-specific splicing complex [nucleoplasm] [Complex:R-HSA-6803522] FGFR2 IIIc-specific splicing complex [nucleoplasm]

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