Reactome | PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA

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PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA Show undefined attributes

authored	[InstanceEdit:6803263] Rothfels, Karen, 2015-10-05
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6803520] Rothfels, Karen, 2015-10-06
dbId	6803523
displayName	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
edited	[InstanceEdit:6803263] Rothfels, Karen, 2015-10-05
eventOf	[Pathway:R-HSA-6803529] FGFR2 alternative splicing - Homo sapiens
input	[Complex:R-HSA-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-71927] HNRNPA1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-71923] PTBP1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803449] An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein [LiteratureReference:6803454] Characterization of cDNAs encoding the polypyrimidine tract-binding protein [LiteratureReference:6803513] hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer [LiteratureReference:6803495] Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
orthologousEvent	[Reaction:R-MMU-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Mus musculus [Reaction:R-CEL-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Caenorhabditis elegans [Reaction:R-XTR-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Xenopus tropicalis [Reaction:R-DRE-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Danio rerio [Reaction:R-SSC-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Sus scrofa [Reaction:R-BTA-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Bos taurus [Reaction:R-CFA-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Canis familiaris [Reaction:R-RNO-6803523] PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA - Rattus norvegicus
output	[Complex:R-HSA-6803522] FGFR2 IIIc-specific splicing complex [nucleoplasm]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851378] Grose, Richard P, 2016-01-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6803523
summation	[Summation:6803507] Repression of FGFR2 exon IIIb splicing in mesenchymal cells ...

Referrals

(hasEvent)

[Pathway:R-HSA-6803529] FGFR2 alternative splicing