Reactome | FGFR2b-specific alternative splicing produces FGFR2b transcript

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FGFR2b-specific alternative splicing produces FGFR2b transcript Show undefined attributes

authored	[InstanceEdit:6803532] Rothfels, Karen, 2015-10-06
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6803837] Rothfels, Karen, 2015-10-07
dbId	6803836
displayName	FGFR2b-specific alternative splicing produces FGFR2b transcript
edited	[InstanceEdit:6803532] Rothfels, Karen, 2015-10-06
eventOf	[Pathway:R-HSA-6803529] FGFR2 alternative splicing - Homo sapiens
input	[Complex:R-HSA-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803478] ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing [LiteratureReference:6803484] Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice [LiteratureReference:6803516] hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc [LiteratureReference:6803488] Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons [LiteratureReference:6803510] The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR2b-specific alternative splicing produces FGFR2b transcript
output	[EntityWithAccessionedSequence:R-HSA-6803827] FGFR2b mature mRNA [nucleoplasm]
regulatedBy	[NegativeRegulation:R-HSA-6803844] Negative regulation by 'FGFR2 IIIc-specific splicing complex [nucleoplasm]' [PositiveRegulation:R-HSA-6803847] Positive regulation by 'FGFR2 IIIb-specific splicing complex [nucleoplasm]'
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851378] Grose, Richard P, 2016-01-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6803836
summation	[Summation:6803835] In epithelial cells, FGFR2 IIIb-specific alternative splicin...

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[Pathway:R-HSA-6803529] FGFR2 alternative splicing

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