Reactome | ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression

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ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression Show undefined attributes

authored	[InstanceEdit:6803263] Rothfels, Karen, 2015-10-05
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6803528] Rothfels, Karen, 2015-10-06
dbId	6803527
displayName	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression
edited	[InstanceEdit:6803263] Rothfels, Karen, 2015-10-05
eventOf	[Pathway:R-HSA-6803529] FGFR2 alternative splicing - Homo sapiens
input	[Complex:R-HSA-6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6803472] ESRP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6803474] ESRP2 [nucleoplasm] [Complex:R-HSA-6803505] hnRNPH1:hnPNPF:RBFOX2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-71949] HNRNPM [nucleoplasm] [DefinedSet:R-HSA-6803501] TIA1/TIAL1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803444] A Non-sequence-specific double-stranded RNA structural element regulates splicing of two mutually exclusive exons of fibroblast growth factor receptor 2 (FGFR2) [LiteratureReference:6803447] A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence [LiteratureReference:6803457] Characterization of sequences and mechanisms through which ISE/ISS-3 regulates FGFR2 splicing [LiteratureReference:6803478] ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing [LiteratureReference:6803484] Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice [LiteratureReference:6803516] hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc [LiteratureReference:6803488] Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons [LiteratureReference:6803510] The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site [LiteratureReference:6803493] Identification of RNA-binding proteins that regulate FGFR2 splicing through the use of sensitive and specific dual color fluorescence minigene assays
maxDepth	1
modified	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
name	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression
orthologousEvent	[Reaction:R-RNO-6803527] ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression - Rattus norvegicus
output	[Complex:R-HSA-6803525] FGFR2 IIIb-specific splicing complex [nucleoplasm]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851378] Grose, Richard P, 2016-01-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6803527
summation	[Summation:6803481] Expression of FGFR2 IIIb splice variant is characteristic of...

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[Pathway:R-HSA-6803529] FGFR2 alternative splicing