Reactome | RAS GTPase mutants don't hydrolyze GTP

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RAS GTPase mutants don't hydrolyze GTP Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802835] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802834
disease	[Disease:1500689] cancer
displayName	RAS GTPase mutants don't hydrolyze GTP
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:9649911] loss_of_function of RAS GTPase mutants:GTP [plasma membrane]
eventOf	[Pathway:R-HSA-9753512] Signaling by RAS GTPase mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-6802908] RAS mutants bind inactive RAF - Homo sapiens
input	[Complex:R-HSA-9649908] RAS GTPase mutants:GTP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6790227] A comprehensive survey of Ras mutations in cancer [LiteratureReference:6790393] RAS oncogenes: weaving a tumorigenic web [LiteratureReference:6799062] Ras history: The saga continues [LiteratureReference:5658234] Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis [LiteratureReference:6790428] The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins [LiteratureReference:6790233] Allosteric modulation of Ras positions Q61 for a direct role in catalysis [LiteratureReference:208211] The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants [LiteratureReference:5658433] Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP [LiteratureReference:5658404] Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras [LiteratureReference:2685012] GEFs and GAPs: critical elements in the control of small G proteins [LiteratureReference:6790229] A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants [LiteratureReference:6790423] The RASopathies [LiteratureReference:6790425] The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation [LiteratureReference:6790346] Germline KRAS mutations cause Noonan syndrome [LiteratureReference:6790237] Biochemical and functional characterization of germ line KRAS mutations
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS GTPase mutants don't hydrolyze GTP
normalReaction	[Reaction:R-HSA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802834
summation	[Summation:6802235] RAS is mutated in 25-30% of human cancers, with the majority...

Referrals

(precedingEvent)	[Reaction:R-HSA-6802908] RAS mutants bind inactive RAF
(hasEvent)	[Pathway:R-HSA-9753512] Signaling by RAS GTPase mutants