Reactome | Signaling by RAS GTPase mutants

Schema > Pathway > Entries

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
created	[InstanceEdit:9753509] Rothfels, Karen, 2021-09-08
crossReference	[DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12020745] Mondo:0004992
dbId	9753512
disease	[Disease:1500689] cancer
displayName	Signaling by RAS GTPase mutants
edited	[InstanceEdit:9754450] Rothfels, Karen, 2021-09-25
eventOf	[Pathway:R-HSA-9649913] RAS GTPase cycle mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-6802834] RAS GTPase mutants don't hydrolyze GTP - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6790227] A comprehensive survey of Ras mutations in cancer [LiteratureReference:6790393] RAS oncogenes: weaving a tumorigenic web [LiteratureReference:5658234] Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis [LiteratureReference:6799062] Ras history: The saga continues
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling by RAS GTPase mutants
normalPathway	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9753512
summation	[Summation:9753511] This pathway describes RAS mutants with decreased intrinsic ...

(hasEvent)

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