Reactome | PLK2 phosphorylates NPM1

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PLK2 phosphorylates NPM1 Show undefined attributes

catalystActivity	[CatalystActivity:10070724] protein serine/threonine kinase activity of PLK2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10070733
displayName	PLK2 phosphorylates NPM1
eventOf	[Pathway:R-MMU-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6801675] PLK2 phosphorylates NPM1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-MMU-3008211] Npm1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PLK2 phosphorylates NPM1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-6801679] phospho-Npm1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6801675
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
(inferredTo)	[Reaction:R-HSA-6801675] PLK2 phosphorylates NPM1