Reactome | PLK2 phosphorylates NPM1

PLK2 phosphorylates NPM1

Stable Identifier

R-HSA-6801675

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        PLK2 phosphorylates NPM1 (Homo sapiens)

General

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PLK2 phosphorylates NPM1 (nucleophosmin) on serine residue S4, which may be necessary to trigger centrosome duplication (Krause and Hoffmann 2010).

Literature References

PubMed ID	Title	Journal	Year
20352051	Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication Krause, A, Hoffmann, I	PLoS ONE	2010

Participants

Input

Output

Participant Of

hasEvent

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Catalyst Activity

Title

protein serine/threonine kinase activity of PLK2 [cytosol]

Physical Entity

PLK2 [cytosol]

Activity

protein serine/threonine kinase activity (0004674)

Orthologous Events

PLK2 phosphorylates NPM1 (Bos taurus)

PLK2 phosphorylates NPM1 (Canis familiaris)

PLK2 phosphorylates NPM1 (Danio rerio)

PLK2 phosphorylates NPM1 (Mus musculus)

PLK2 phosphorylates NPM1 (Rattus norvegicus)

PLK2 phosphorylates NPM1 (Sus scrofa)

PLK2 phosphorylates NPM1 (Xenopus tropicalis)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-02)