Reactome | HIPK2 phosphorylates TP53

Schema > Reaction > Entries

HIPK2 phosphorylates TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6799405] protein serine/threonine kinase activity of TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6799385] Orlic-Milacic, Marija, 2015-09-24
dbId	6799409
displayName	HIPK2 phosphorylates TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
followingEvent	[Reaction:R-HSA-6798615] TP53 binds the TP53AIP1 gene - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-3215242] TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6799406] Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis [LiteratureReference:6799394] Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 [LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity [LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	HIPK2 phosphorylates TP53
orthologousEvent	[Reaction:R-DRE-6799409] HIPK2 phosphorylates TP53 - Danio rerio [Reaction:R-DME-6799409] HIPK2 phosphorylates TP53 - Drosophila melanogaster [Reaction:R-SSC-6799409] HIPK2 phosphorylates TP53 - Sus scrofa [Reaction:R-BTA-6799409] HIPK2 phosphorylates TP53 - Bos taurus [Reaction:R-CFA-6799409] HIPK2 phosphorylates TP53 - Canis familiaris [Reaction:R-MMU-6799409] HIPK2 phosphorylates TP53 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-6799392] p-HIPK2:PIN1 [nucleoplasm] [Complex:R-HSA-6798371] p-S15,S20,S46-TP53 Tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3215226] TP53INP1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3215251] TP53INP1 and HIPK2 bind TP53 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6799409
summation	[Summation:6799381] HIPK2, activated by autophosphorylation in response to DNA d...

Referrals

(precedingEvent)	[Reaction:R-HSA-6798615] TP53 binds the TP53AIP1 gene
(hasEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation