Reactome | TP53 family members stimulate CASP1 expression

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TP53 family members stimulate CASP1 expression Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:6798087] Orlic-Milacic, Marija, 2015-09-16
dbId	6798081
displayName	TP53 family members stimulate CASP1 expression
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6798089] CASP1 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6798097] Caspase-1 is a novel target of p63 in tumor suppression [LiteratureReference:6798096] Direct transcriptional activation of human caspase-1 by tumor suppressor p53 [LiteratureReference:6798080] Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin [LiteratureReference:6798118] Molecular cloning of the interleukin-1 beta converting enzyme [LiteratureReference:6798110] Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 [LiteratureReference:451670] Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 family members stimulate CASP1 expression
output	[EntityWithAccessionedSequence:R-HSA-448692] CASP1(1-404) [cytosol]
precedingEvent	[Reaction:R-HSA-6798082] TP53 family members bind the CASP1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-6798105] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642587] Positive gene expression regulation by '(p-S15,S20-TP53,TP63,TP73):CASP1 Gene [nucleoplasm]' Direct transcriptional activation of human caspase-1 by tumor suppressor p53
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6798081
summation	[Summation:6798101] Upon binding to the p53 response element in the promoter of ...

Referrals

(hasEvent)

[Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases