TP53 family members stimulate CASP1 expression

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Reaction [omitted]
Homo sapiens
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Upon binding to the p53 response element in the promoter of the caspase-1 (CASP1) gene, TP53 (p53), TP63 (p63) or TP73 (p73) stimulates transcription of CASP1 (Gupta et al. 2001, Jain et al. 2005, Celardo et al. 2013). CASP1 acts as the interleukin-1 beta (IL1B) converting enzyme (Cerretti et al. 1992) and is involved in the inflammation-related cell death - pyroptosis (Miura et al. 1993, Brough and Rothwell 2007).

Literature References
PubMed ID Title Journal Year
16135520 Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin

Jain, N, Gupta, S, Sudhakar, Ch, Radha, V, Swarup, G

J. Biol. Chem. 2005
8242741 Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

Miura, M, Zhu, H, Rotello, R, Hartwieg, EA, Yuan, J

Cell 1993
11278253 Direct transcriptional activation of human caspase-1 by tumor suppressor p53

Gupta, S, Radha, V, Furukawa, Y, Swarup, G

J. Biol. Chem. 2001
23703390 Caspase-1 is a novel target of p63 in tumor suppression

Celardo, I, Grespi, F, Antonov, A, Bernassola, F, Garabadgiu, AV, Melino, G, Amelio, I

Cell Death Dis 2013
1373520 Molecular cloning of the interleukin-1 beta converting enzyme

Cerretti, DP, Kozlosky, CJ, Mosley, B, Nelson, N, Van Ness, K, Greenstreet, TA, March, CJ, Kronheim, SR, Druck, T, Cannizzaro, LA

Science 1992
17284521 Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Brough, D, Rothwell, NJ

J Cell Sci 2007
This event is regulated
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