Reactome | TP53 Regulates Transcription of Caspase Activators and Caspases

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TP53 Regulates Transcription of Caspase Activators and Caspases Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6803212] Orlic-Milacic, Marija, 2015-10-05
crossReference	[DatabaseIdentifier:12325492] BioModels Database:BIOMD0000000287 [DatabaseIdentifier:12325572] BioModels Database:BIOMD0000000188 [DatabaseIdentifier:12325450] BioModels Database:BIOMD0000000939 [DatabaseIdentifier:12325562] BioModels Database:BIOMD0000000943 [DatabaseIdentifier:12325402] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12325574] BioModels Database:BIOMD0000000634
dbId	6803207
displayName	TP53 Regulates Transcription of Caspase Activators and Caspases
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-6791349] TP53 binds the APAF1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-6791348] TP53 stimulates APAF1 gene expression - Homo sapiens [Reaction:R-HSA-6800279] TP53 binds the PIDD1 gene - Homo sapiens [BlackBoxEvent:R-HSA-6800396] TP53 stimulates PIDD1 expression - Homo sapiens [Reaction:R-HSA-6800490] ATM phosphorylates PIDD1 - Homo sapiens [Reaction:R-HSA-6800793] PIDD1 translocates to the cytosol - Homo sapiens [Reaction:R-HSA-6800794] PIDD1 associates with CRADD - Homo sapiens [Reaction:R-HSA-6800798] The PIDDosome binds CASP2 - Homo sapiens [Reaction:R-HSA-6800797] The PIDDosome activates CASP2 - Homo sapiens [Reaction:R-HSA-6801355] TP53 binds the NLRC4 gene - Homo sapiens [BlackBoxEvent:R-HSA-6801415] TP53 stimulates NLRC4 expression - Homo sapiens [Reaction:R-HSA-6798082] TP53 family members bind the CASP1 gene - Homo sapiens [BlackBoxEvent:R-HSA-6798081] TP53 family members stimulate CASP1 expression - Homo sapiens [Reaction:R-HSA-6798129] TP53 binds the CASP6 gene - Homo sapiens [BlackBoxEvent:R-HSA-6798126] TP53 stimulates CASP6 expression - Homo sapiens [Reaction:R-HSA-6798138] TP53 binds the CASP10 gene - Homo sapiens [BlackBoxEvent:R-HSA-6798139] TP53 stimulates CASP10 expression - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6791355] APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis [LiteratureReference:6800275] Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis [LiteratureReference:6801360] Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis [LiteratureReference:6798096] Direct transcriptional activation of human caspase-1 by tumor suppressor p53 [LiteratureReference:6798128] Apoptotic threshold is lowered by p53 transactivation of caspase-6 [LiteratureReference:6798143] Caspase 10 levels are increased following DNA damage in a p53-dependent manner [LiteratureReference:451670] Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	TP53 Regulates Transcription of Caspase Activators and Caspases
orthologousEvent	[Pathway:R-DME-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Drosophila melanogaster [Pathway:R-SSC-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Sus scrofa [Pathway:R-BTA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Bos taurus [Pathway:R-CFA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Canis familiaris [Pathway:R-RNO-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Rattus norvegicus [Pathway:R-MMU-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Mus musculus
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6803207
summation	[Summation:6803206] TP53 (p53) transcriptionally regulates cytosolic caspase act...

Referrals

(hasEvent)

[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes

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