Reactome | ASPG hydrolyses L-Asn to L-Asp

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ASPG hydrolyses L-Asn to L-Asp Show undefined attributes

authored	[InstanceEdit:6797639] Jassal, Bijay, 2015-09-15
catalystActivity	[CatalystActivity:6797637] asparaginase activity of ASPG [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6797639] Jassal, Bijay, 2015-09-15
crossReference	[DatabaseIdentifier:12667532] RHEA:21017 [DatabaseIdentifier:9925770] RHEA:21017
dbId	6797627
displayName	ASPG hydrolyses L-Asn to L-Asp
edited	[InstanceEdit:6797639] Jassal, Bijay, 2015-09-15
eventOf	[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs - Homo sapiens [Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29642] L-Asn [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6797646] Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ASPG hydrolyses L-Asn to L-Asp H2O + L-asparagine => L-aspartate + NH4(+)
negativePrecedingEvent	[NegativePrecedingEvent:9930396] Futile Cycle: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
orthologousEvent	[Reaction:R-DDI-6797627] ASPG hydrolyses L-Asn to L-Asp - Dictyostelium discoideum [Reaction:R-CEL-6797627] ASPG hydrolyses L-Asn to L-Asp - Caenorhabditis elegans [Reaction:R-DME-6797627] ASPG hydrolyses L-Asn to L-Asp - Drosophila melanogaster [Reaction:R-GGA-6797627] ASPG hydrolyses L-Asn to L-Asp - Gallus gallus [Reaction:R-XTR-6797627] ASPG hydrolyses L-Asn to L-Asp - Xenopus tropicalis [Reaction:R-SSC-6797627] ASPG hydrolyses L-Asn to L-Asp - Sus scrofa [Reaction:R-BTA-6797627] ASPG hydrolyses L-Asn to L-Asp - Bos taurus [Reaction:R-CFA-6797627] ASPG hydrolyses L-Asn to L-Asp - Canis familiaris [Reaction:R-RNO-6797627] ASPG hydrolyses L-Asn to L-Asp - Rattus norvegicus [Reaction:R-MMU-6797627] ASPG hydrolyses L-Asn to L-Asp - Mus musculus
output	[SimpleEntity:R-ALL-29448] L-Asp [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6797627
summation	[Summation:6797636] L-Asparaginases can catalyse the hydrolysis of L-asparagine ...
updateTrackers	[UpdateTracker:9928416] Update Tracker - [Reaction:6797627] ASPG hydrolyses L-Asn to L-Asp - v91:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9928416] Update Tracker - [Reaction:6797627] ASPG hydrolyses L-Asn to L-Asp - v91:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism
(precedingEvent)	[Reaction:R-HSA-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs [Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [NegativePrecedingEvent:9930400] Futile Cycle: ASPG hydrolyses L-Asn to L-Asp