ASPG hydrolyses L-Asn to L-Asp

Stable Identifier
R-HSA-6797627
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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L-Asparaginases can catalyse the hydrolysis of L-asparagine (L-Asn) to L-aspartic acid (L-Asp) and ammonia (NH3) in organisms ranging from bacteria to humans. Bacterial type II versions of the enzyme serve as therapeutics for the treatment of acute lymphoblastic leukemia despite adverse side effects. The human equivalent (60 kDa lysophospholipase, ASPG) has shown to possess L-Asparaginase activity and may be a potential alternative replacement for bacterial enzymes as a leukemia therapeutic in the future (Karamitros & Konrad 2014).

Literature References
PubMed ID Title Journal Year
24657844 Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine

Karamitros, CS, Konrad, M

J. Biol. Chem. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
asparaginase activity of ASPG [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created