ASPG hydrolyses L-Asn to L-Asp

Stable Identifier
R-HSA-6797627
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
H2O + L-asparagine => L-aspartate + NH4(+)
ReviewStatus
5/5
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ASPG hydrolyses L-Asn to L-Asp
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L-Asparaginases can catalyse the hydrolysis of L-asparagine (L-Asn) to L-aspartic acid (L-Asp) and ammonia (NH3) in organisms ranging from bacteria to humans. Bacterial type II versions of the enzyme serve as therapeutics for the treatment of acute lymphoblastic leukemia despite adverse side effects. The human equivalent (60 kDa lysophospholipase, ASPG) has shown to possess L-Asparaginase activity and may be a potential alternative replacement for bacterial enzymes as a leukemia therapeutic in the future (Karamitros & Konrad 2014).
Literature References
PubMed ID Title Journal Year
24657844 Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine

Konrad, M, Karamitros, CS

J. Biol. Chem. 2014
Participants
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Output
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as an event of
Catalyst Activity

asparaginase activity of ASPG [cytosol]

Physical Entity
ASPG [cytosol] (Homo sapiens)
Activity
asparaginase activity (GO:0004067)
Orthologous Events
ASPG hydrolyses L-Asn to L-Asp (Bos taurus)
ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)
ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)
ASPG hydrolyses L-Asn to L-Asp (Dictyostelium discoideum)
ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)
ASPG hydrolyses L-Asn to L-Asp (Gallus gallus)
ASPG hydrolyses L-Asn to L-Asp (Mus musculus)
ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)
ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)
ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
Jassal, B  (2015-09-15)
Reviewed
D'Eustachio, P  (2016-01-11)
D'Eustachio, P  (2024-11-08)
Created
Jassal, B  (2015-09-15)
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