Expression of BCL2, BCL2L1

Stable Identifier
R-HSA-6790025
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial outer membrane, nucleoplasm
ReviewStatus
5/5
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Expression of BCL2, BCL2L1
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014), including the mitochondrial outer membrane protein genes Apoptosis regulator BCL2 (Bhattacharya et al. 2005) and Bcl-2-like protein 1 (BCL2L1, Bcl-XL) (Catlett-Falcone et al. 1999).

Severe acute respiratory syndrome coronavirus type 1 (SARS-CoV-1) E protein was reported to induce apoptosis by sequestering anti-apoptotic BCL2L1 to membranes of the endoplasmic reticulum (ER) and Golgi, where viral E protein is located (Yang Y et al. 2005). Similar findings were reported for SARS-CoV-1 7a (Tan YX et al. 2007).

Literature References
PubMed ID Title Journal Year
16048438 STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells

Bhattacharya, S, Ray, RM, Johnson, LR

Biochem. J. 2005
10023775 Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

Nuñez, G, Fernández-Luna, JL, Landowski, TH, Catlett-Falcone, R, Jove, R, Ciliberto, G, Turkson, J, Moscinski, L, Oshiro, MM, Dalton, WS, Levitzki, A, Savino, R

Immunity 1999
24743777 STAT3 Target Genes Relevant to Human Cancers

Lo, HW, Carpenter, RL

Cancers (Basel) 2014
Participants
Input
Output
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This event is regulated
Positively by
Regulator
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-08-06)
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