Reactome | ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins

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ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins Show undefined attributes

authored	[InstanceEdit:6788649] Jassal, Bijay, 2015-07-24
catalystActivity	[CatalystActivity:6788648] protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity of ICMT:Zn2+ [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:6788649] Jassal, Bijay, 2015-07-24
dbId	6788650
displayName	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins
edited	[InstanceEdit:6788649] Jassal, Bijay, 2015-07-24
eventOf	[Pathway:R-HSA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-6788753] S-FARN-Cys [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6788767] Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe [LiteratureReference:6788745] Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT [LiteratureReference:6788770] Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites [LiteratureReference:6788765] An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins
orthologousEvent	[Reaction:R-PFA-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Plasmodium falciparum [Reaction:R-SCE-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Saccharomyces cerevisiae [Reaction:R-SPO-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Schizosaccharomyces pombe [Reaction:R-DDI-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Dictyostelium discoideum [Reaction:R-CEL-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Caenorhabditis elegans [Reaction:R-DME-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Drosophila melanogaster [Reaction:R-GGA-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Gallus gallus [Reaction:R-XTR-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Xenopus tropicalis [Reaction:R-DRE-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Danio rerio [Reaction:R-SSC-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Sus scrofa [Reaction:R-BTA-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Bos taurus [Reaction:R-RNO-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Rattus norvegicus [Reaction:R-MMU-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Mus musculus
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-6788758] S-FARN-CME [cytosol]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6788650
summation	[Summation:6788752] Protein-S-isoprenylcysteine O-methyltransferase (ICMT) media...

Referrals

(hasEvent)

[Pathway:R-HSA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

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