ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins

Stable Identifier
R-HSA-6788650
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins
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Protein-S-isoprenylcysteine O-methyltransferase (ICMT) mediates the post-translational methyl esterification of C-terminal CAAX motifs in prenylated proteins such as the oncoprotein RAS and related GTPases, neutralising the negative charge of prenylcysteine species and thereby determining their subcellular localisation and correct biological function (Wright et al. 2009, Yang et al. 2011). ICMT may serve as a therapeutic target in cancer development (Lau et al. 2014, Diver et al. 2014).
Literature References
PubMed ID Title Journal Year
22195972 Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT

Zhang, Z, Yang, J, Kulkarni, K, Mas-Droux, C, Manolaridis, I, Barford, D, Dodd, RB

Mol. Cell 2011
24971579 An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

Guo, D, Yang, T, Wirawan, M, Casey, PJ, Lau, HY, Wang, M, Go, ML, Ramanujulu, PM

Cancer Biol. Ther. 2014
19158273 Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe

Court, H, Casey, PJ, Philips, MR, Wright, LP, Ahearn, IM, Mor, A

Mol. Cell. Biol. 2009
25059662 Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites

Long, SB, Diver, MM

J. Biol. Chem. 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity of ICMT:Zn2+ [endoplasmic reticulum membrane]

Physical Entity
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Activity
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity (GO:0004671)
Orthologous Events
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)
Authored
Jassal, B  (2015-07-24)
Reviewed
D'Eustachio, P  (2015-09-14)
Created
Jassal, B  (2015-07-24)
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