Reactome | ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins

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ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins Show undefined attributes

catalystActivity	[CatalystActivity:11031273] protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity of ICMT:Zn2+ [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11031275
displayName	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins
eventOf	[Pathway:R-DDI-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-6788753] S-FARN-Cys [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-6788758] S-FARN-CME [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-6788650
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(inferredTo)	[Reaction:R-HSA-6788650] ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins

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