Reactome | IL-6-type cytokine receptor ligand interactions

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IL-6-type cytokine receptor ligand interactions Show undefined attributes

authored	[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
created	[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
crossReference	[DatabaseIdentifier:12819655] BioModels Database:BIOMD0000000314 [DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313
dbId	6788467
displayName	IL-6-type cytokine receptor ligand interactions
edited	[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
eventOf	[Pathway:R-HSA-6783589] Interleukin-6 family signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5696491] CNTF binds CNTFR complex - Homo sapiens [Reaction:R-HSA-6783670] CRLF1 binds CLCF1 - Homo sapiens [Reaction:R-HSA-5696490] CRLF1:CLCF1 binds CNTRF - Homo sapiens [Reaction:R-HSA-6783530] gp130:JAKs bind CNTFR - Homo sapiens [Reaction:R-HSA-6784189] JAKs bind LIFR - Homo sapiens [Reaction:R-HSA-6783556] LIFR:JAKs bind gp130:JAKs:CNTFR - Homo sapiens [Reaction:R-HSA-449829] IL11 binds IL11RA - Homo sapiens [Reaction:R-HSA-449976] IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) - Homo sapiens [Reaction:R-HSA-6783681] LIF binds LIFR - Homo sapiens [Reaction:R-HSA-6784204] JAKs bind OSMR - Homo sapiens [Reaction:R-HSA-6783552] OSM binds LIFR:JAKs,OSMR:JAKs - Homo sapiens [Reaction:R-HSA-5696482] CTF1 binds LIFR:JAKs - Homo sapiens [Reaction:R-HSA-6783524] OSM,LIF,CTF1 receptor complex binds gp130 - Homo sapiens [BlackBoxEvent:R-HSA-448660] IL31:IL31RA:JAK1 binds OSMR:JAK1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:1112544] Principles of interleukin (IL)-6-type cytokine signalling and its regulation [LiteratureReference:6783652] Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	IL-6-type cytokine receptor ligand interactions
orthologousEvent	[Pathway:R-SSC-6788467] IL-6-type cytokine receptor ligand interactions - Sus scrofa [Pathway:R-GGA-6788467] IL-6-type cytokine receptor ligand interactions - Gallus gallus [Pathway:R-XTR-6788467] IL-6-type cytokine receptor ligand interactions - Xenopus tropicalis [Pathway:R-DRE-6788467] IL-6-type cytokine receptor ligand interactions - Danio rerio [Pathway:R-BTA-6788467] IL-6-type cytokine receptor ligand interactions - Bos taurus [Pathway:R-CFA-6788467] IL-6-type cytokine receptor ligand interactions - Canis familiaris [Pathway:R-RNO-6788467] IL-6-type cytokine receptor ligand interactions - Rattus norvegicus [Pathway:R-MMU-6788467] IL-6-type cytokine receptor ligand interactions - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6788467
summation	[Summation:6788466] The members involved in (interleukin)-6-type cytokine signal...
updateTrackers	[UpdateTracker:9781406] Update Tracker - [Pathway:6788467] IL-6-type cytokine receptor ligand interactions - v61:[addHasEvent, updateContainedRLE] [UpdateTracker:9780759] Update Tracker - [Pathway:6788467] IL-6-type cytokine receptor ligand interactions - v62:[updateContainedRLE] [UpdateTracker:9781933] Update Tracker - [Pathway:6788467] IL-6-type cytokine receptor ligand interactions - v60:[removeHasEvent]

Referrals

(updatedInstance)

[UpdateTracker:9781406] Update Tracker - [Pathway:6788467] IL-6-type cytokine receptor ligand interactions - v61:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780759] Update Tracker - [Pathway:6788467] IL-6-type cytokine receptor ligand interactions - v62:[updateContainedRLE]
[UpdateTracker:9781933] Update Tracker - [Pathway:6788467] IL-6-type cytokine receptor ligand interactions - v60:[removeHasEvent]

(hasEvent)

[Pathway:R-HSA-6783589] Interleukin-6 family signaling

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