Reactome | IL-6-type cytokine receptor ligand interactions

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IL-6-type cytokine receptor ligand interactions Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330431
displayName	IL-6-type cytokine receptor ligand interactions
eventOf	[Pathway:R-CFA-6783589] Interleukin-6 family signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-6783670] CRLF1 binds CLCF1 - Canis familiaris [Reaction:R-CFA-5696490] CRLF1:CLCF1 binds CNTRF - Canis familiaris [Reaction:R-CFA-6783530] gp130:JAKs bind CNTFR - Canis familiaris [Reaction:R-CFA-6784189] JAKs bind LIFR - Canis familiaris [Reaction:R-CFA-6783556] LIFR:JAKs bind gp130:JAKs:CNTFR - Canis familiaris [Reaction:R-CFA-449829] IL11 binds IL11RA - Canis familiaris [Reaction:R-CFA-449976] IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) - Canis familiaris [Reaction:R-CFA-6783681] LIF binds LIFR - Canis familiaris [Reaction:R-CFA-6784204] JAKs bind OSMR - Canis familiaris [Reaction:R-CFA-6783552] OSM binds LIFR:JAKs,OSMR:JAKs - Canis familiaris [Reaction:R-CFA-5696482] CTF1 binds LIFR:JAKs - Canis familiaris [Reaction:R-CFA-6783524] OSM,LIF,CTF1 receptor complex binds gp130 - Canis familiaris [BlackBoxEvent:R-CFA-448660] IL31:IL31RA:JAK1 binds OSMR:JAK1 - Canis familiaris
inferredFrom	[Pathway:R-HSA-6788467] IL-6-type cytokine receptor ligand interactions - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IL-6-type cytokine receptor ligand interactions
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-6788467
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6783589] Interleukin-6 family signaling
(inferredTo)	[Pathway:R-HSA-6788467] IL-6-type cytokine receptor ligand interactions

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