Reactome | IL-6-type cytokine receptor ligand interactions

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IL-6-type cytokine receptor ligand interactions Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100367
displayName	IL-6-type cytokine receptor ligand interactions
eventOf	[Pathway:R-MMU-6783589] Interleukin-6 family signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-5696491] CNTF binds CNTFR complex - Mus musculus [Reaction:R-MMU-6783670] CRLF1 binds CLCF1 - Mus musculus [Reaction:R-MMU-5696490] CRLF1:CLCF1 binds CNTRF - Mus musculus [Reaction:R-MMU-6783530] gp130:JAKs bind CNTFR - Mus musculus [Reaction:R-MMU-6784189] JAKs bind LIFR - Mus musculus [Reaction:R-MMU-6783556] LIFR:JAKs bind gp130:JAKs:CNTFR - Mus musculus [Reaction:R-MMU-449829] IL11 binds IL11RA - Mus musculus [Reaction:R-MMU-449976] IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) - Mus musculus [Reaction:R-MMU-6783681] LIF binds LIFR - Mus musculus [Reaction:R-MMU-6784204] JAKs bind OSMR - Mus musculus [Reaction:R-MMU-6783552] OSM binds LIFR:JAKs,OSMR:JAKs - Mus musculus [Reaction:R-MMU-5696482] CTF1 binds LIFR:JAKs - Mus musculus [Reaction:R-MMU-6783524] OSM,LIF,CTF1 receptor complex binds gp130 - Mus musculus [BlackBoxEvent:R-MMU-448660] IL31:IL31RA:JAK1 binds OSMR:JAK1 - Mus musculus
inferredFrom	[Pathway:R-HSA-6788467] IL-6-type cytokine receptor ligand interactions - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IL-6-type cytokine receptor ligand interactions
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-6788467
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6783589] Interleukin-6 family signaling
(inferredTo)	[Pathway:R-HSA-6788467] IL-6-type cytokine receptor ligand interactions

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