Reactome | DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA

Schema > Reaction > Entries

DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA Show undefined attributes

authored	[InstanceEdit:6786719] Jassal, Bijay, 2015-07-10
catalystActivity	[CatalystActivity:6786714] trans-2-enoyl-CoA reductase (NADPH) activity of DECR2 [peroxisomal membrane]
catalystActivityReference	[CatalystActivityReference:9914129] trans-2-enoyl-CoA reductase (NADPH) activity of DECR2 [peroxisomal membrane] Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase
category	transition
compartment	[Compartment:17951] peroxisomal matrix [Compartment:17947] peroxisomal membrane
created	[InstanceEdit:6786719] Jassal, Bijay, 2015-07-10
crossReference	[DatabaseIdentifier:12667716] RHEA:45913
dbId	6786720
displayName	DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA
edited	[InstanceEdit:6786719] Jassal, Bijay, 2015-07-10
eventOf	[Pathway:R-HSA-390247] Beta-oxidation of very long chain fatty acids - Homo sapiens
input	[SimpleEntity:R-ALL-9914117] (2E,4E)-dienoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-113602] NADPH [peroxisomal matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6786718] Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase [LiteratureReference:6786716] Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal ?-oxidation of unsaturated fatty acids
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
orthologousEvent	[Reaction:R-SCE-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Saccharomyces cerevisiae [Reaction:R-GGA-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Gallus gallus [Reaction:R-DRE-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Danio rerio [Reaction:R-SSC-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Sus scrofa [Reaction:R-BTA-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Bos taurus [Reaction:R-CFA-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Canis familiaris [Reaction:R-RNO-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Rattus norvegicus [Reaction:R-MMU-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-9914123] 4,5-saturated-(3E)-enoyl-CoA(4-) [peroxisomal matrix] [SimpleEntity:R-ALL-389556] NADP+ [peroxisomal matrix]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14 [InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6786720
summation	[Summation:6786724] Saturated and unsaturated fats can undergo beta-oxidation in...
updateTrackers	[UpdateTracker:9919428] Update Tracker - [Reaction:6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - v90:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9919428] Update Tracker - [Reaction:6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - v90:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-390247] Beta-oxidation of very long chain fatty acids

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