Reactome | DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA

Schema > Reaction > Entries

DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10798707] trans-2-enoyl-CoA reductase (NADPH) activity of DECR2 [peroxisomal membrane]
category	transition
compartment	[Compartment:17951] peroxisomal matrix [Compartment:17947] peroxisomal membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798709
displayName	DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA
eventOf	[Pathway:R-GGA-390247] Beta-oxidation of very long chain fatty acids - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-9914117] (2E,4E)-dienoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-113602] NADPH [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
output	[SimpleEntity:R-ALL-9914123] 4,5-saturated-(3E)-enoyl-CoA(4-) [peroxisomal matrix] [SimpleEntity:R-ALL-389556] NADP+ [peroxisomal matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6786720
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-390247] Beta-oxidation of very long chain fatty acids
(inferredTo)	[Reaction:R-HSA-6786720] DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA

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