Reactome | tRNA modification in the nucleus and cytosol

Schema > Pathway > Entries

tRNA modification in the nucleus and cytosol Show undefined attributes

authored	[InstanceEdit:5696820] May, Bruce, 2015-05-30
created	[InstanceEdit:6782319] May, Bruce, 2015-06-06
dbId	6782315
displayName	tRNA modification in the nucleus and cytosol
doi	10.3180/R-HSA-6782315.8
edited	[InstanceEdit:5696820] May, Bruce, 2015-05-30
eventOf	[Pathway:R-HSA-72306] tRNA processing - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6782336] ADAT1 deaminates adenosine-37 in tRNA(Ala) - Homo sapiens [Reaction:R-HSA-6782311] ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs - Homo sapiens [Reaction:R-HSA-6786500] ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 - Homo sapiens [BlackBoxEvent:R-HSA-6786571] CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 - Homo sapiens [Reaction:R-HSA-6782264] CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs - Homo sapiens [Reaction:R-HSA-6782296] DUS2:EPRS reduces uridine to dihydrouridine in tRNAs - Homo sapiens [Reaction:R-HSA-6784494] KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs - Homo sapiens [Reaction:R-HSA-9024159] FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) - Homo sapiens [Reaction:R-HSA-9024161] FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) - Homo sapiens [Reaction:R-HSA-6786567] KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine - Homo sapiens [Reaction:R-HSA-6782286] METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 - Homo sapiens [Reaction:R-HSA-6782388] NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) - Homo sapiens [Reaction:R-HSA-6785438] NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) - Homo sapiens [Reaction:R-HSA-6785409] NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) - Homo sapiens [Reaction:R-HSA-8932765] NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) - Homo sapiens [Reaction:R-HSA-6782381] PUS1 isoform 2 isomerizes uridine residues to pseudouridine residues in the anticodon stems of tRNAs - Homo sapiens [Reaction:R-HSA-8870289] PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA - Homo sapiens [Reaction:R-HSA-6786583] PUS7 isomerizes uridine to pseudouridine in tRNAs - Homo sapiens [Reaction:R-HSA-9942295] QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate - Homo sapiens [Reaction:R-HSA-6782443] QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) - Homo sapiens [Pathway:R-HSA-6782861] Synthesis of wybutosine at G37 of tRNA(Phe) - Homo sapiens [Reaction:R-HSA-6782419] TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) - Homo sapiens [Reaction:R-HSA-6782434] THG1L transfers GMP to 5' end of tRNA(His) - Homo sapiens [Reaction:R-HSA-6784462] TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs - Homo sapiens [Reaction:R-HSA-6782416] TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) - Homo sapiens [Reaction:R-HSA-6786621] TRMT10A methylates guanosine-9 in tRNA - Homo sapiens [Reaction:R-HSA-6786501] TRMT11:TRMT112 methylates guanosine-10 in tRNA - Homo sapiens [Reaction:R-HSA-6783492] TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) - Homo sapiens [Reaction:R-HSA-6788684] TRMT13 2'-O-methylates cytidine-4 in tRNA - Homo sapiens [Reaction:R-HSA-6788668] TRMT13 2'-O-methylates adenosine-4 in tRNA - Homo sapiens [Reaction:R-HSA-6788707] TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-12-18
literatureReference	[LiteratureReference:6782339] Transfer RNA modifications: nature's combinatorial chemistry playground [LiteratureReference:6782248] Chemistry enters nucleic acids biology: enzymatic mechanisms of RNA modification [LiteratureReference:6782253] tRNA modifications regulate translation during cellular stress [LiteratureReference:6784559] The pivotal regulatory landscape of RNA modifications [LiteratureReference:6784551] Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland [LiteratureReference:6785486] Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy [LiteratureReference:6787572] Role of tRNA modifications in human diseases [LiteratureReference:6792647] Modify or die?--RNA modification defects in metazoans
maxDepth	3
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	tRNA modification in the nucleus and cytosol
orthologousEvent	[Pathway:R-SPO-6782315] tRNA modification in the nucleus and cytosol - Schizosaccharomyces pombe [Pathway:R-DDI-6782315] tRNA modification in the nucleus and cytosol - Dictyostelium discoideum [Pathway:R-CEL-6782315] tRNA modification in the nucleus and cytosol - Caenorhabditis elegans [Pathway:R-DME-6782315] tRNA modification in the nucleus and cytosol - Drosophila melanogaster [Pathway:R-MMU-6782315] tRNA modification in the nucleus and cytosol - Mus musculus [Pathway:R-RNO-6782315] tRNA modification in the nucleus and cytosol - Rattus norvegicus [Pathway:R-CFA-6782315] tRNA modification in the nucleus and cytosol - Canis familiaris [Pathway:R-BTA-6782315] tRNA modification in the nucleus and cytosol - Bos taurus [Pathway:R-SSC-6782315] tRNA modification in the nucleus and cytosol - Sus scrofa [Pathway:R-DRE-6782315] tRNA modification in the nucleus and cytosol - Danio rerio [Pathway:R-XTR-6782315] tRNA modification in the nucleus and cytosol - Xenopus tropicalis [Pathway:R-GGA-6782315] tRNA modification in the nucleus and cytosol - Gallus gallus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6782315
summation	[Summation:6785457] At least 92 distinct tRNA nucleotide base modifications have...
updateTrackers	[UpdateTracker:9782994] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v58:[addHasEvent] [UpdateTracker:9780396] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v63:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9783983] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v55:[addLiteratureReference, modifyText] [UpdateTracker:9953615] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v93:[removeHasEvent]

Referrals

(hasEvent)

[Pathway:R-HSA-72306] tRNA processing

(updatedInstance)

[UpdateTracker:9782994] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v58:[addHasEvent]
[UpdateTracker:9780396] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v63:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9783983] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v55:[addLiteratureReference, modifyText]
[UpdateTracker:9953615] Update Tracker - [Pathway:6782315] tRNA modification in the nucleus and cytosol - v93:[removeHasEvent]

Cite Us!