Reactome | NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)

Schema > Reaction > Entries

NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) Show undefined attributes

authored	[InstanceEdit:6785394] May, Bruce, 2015-06-27
catalystActivity	[CatalystActivity:6782357] tRNA (cytidine-5-)-methyltransferase activity of NSUN2 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643785] tRNA (cytosine-5-)-methyltransferase activity of NSUN2 [nucleoplasm] Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA)
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6785432] May, Bruce, 2015-06-27
dbId	6785409
displayName	NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)
edited	[InstanceEdit:6785394] May, Bruce, 2015-06-27
eventOf	[Pathway:R-HSA-6782315] tRNA modification in the nucleus and cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
inferredFrom	[Reaction:R-SCE-6790149] NCL1 (TRM4) methylates cytidine-49 of tRNA(Asp) yielding 5-methylcytidine-46 - Saccharomyces cerevisiae
input	2 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [GenomeEncodedEntity:R-HSA-6785426] tRNA(Asp)(GUC) containing C-48,C-49 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6785423] Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA [LiteratureReference:6782366] Identification of direct targets and modified bases of RNA cytosine methyltransferases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)
output	2 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [GenomeEncodedEntity:R-HSA-6785430] tRNA(Asp)(GUC) containing 5-mC-48,49 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5696807] TRNT1 polymerizes CCA at the 3' end of pre-tRNA - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6785409
summation	[Summation:6785407] NSUN2 transfers methyl groups from S-adenosylmethionine to t...

Referrals

(hasEvent)	[Pathway:R-HSA-6782315] tRNA modification in the nucleus and cytosol
(inferredTo)	[Reaction:R-SCE-6790149] NCL1 (TRM4) methylates cytidine-49 of tRNA(Asp) yielding 5-methylcytidine-46

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