NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)

Stable Identifier
R-HSA-6785409
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)
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NSUN2 transfers methyl groups from S-adenosylmethionine to the 5 positions of cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Squires et al. 2012, Khoddami et al. 2013).
Literature References
PubMed ID Title Journal Year
23604283 Identification of direct targets and modified bases of RNA cytosine methyltransferases

Khoddami, V, Cairns, BR

Nat. Biotechnol. 2013
22344696 Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Squires, JE, Patel, HR, Nousch, M, Sibbritt, T, Humphreys, DT, Parker, BJ, Suter, CM, Preiss, T

Nucleic Acids Res. 2012
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (cytidine-5-)-methyltransferase activity of NSUN2 [nucleoplasm]

Physical Entity
NSUN2 [nucleoplasm] (Homo sapiens)
Activity
tRNA (cytidine-5-)-methyltransferase activity (GO:0016428)
Inferred From
NCL1 (TRM4) methylates cytidine-49 of tRNA(Asp) yielding 5-methylcytidine-46 (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-27)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-27)
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