NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)

Stable Identifier
R-HSA-6785409
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)
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NSUN2 transfers methyl groups from S-adenosylmethionine to the 5 positions of cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Squires et al. 2012, Khoddami et al. 2013).
Literature References
PubMed ID Title Journal Year
23604283 Identification of direct targets and modified bases of RNA cytosine methyltransferases

Cairns, BR, Khoddami, V

Nat. Biotechnol. 2013
22344696 Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Humphreys, DT, Patel, HR, Squires, JE, Preiss, T, Sibbritt, T, Nousch, M, Suter, CM, Parker, BJ

Nucleic Acids Res. 2012
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (cytidine-5-)-methyltransferase activity of NSUN2 [nucleoplasm]

Physical Entity
NSUN2 [nucleoplasm] (Homo sapiens)
Activity
tRNA (cytidine-5-)-methyltransferase activity (GO:0016428)
Inferred From
NCL1 (TRM4) methylates cytidine-49 of tRNA(Asp) yielding 5-methylcytidine-46 (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-27)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-27)
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