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Entries
TRNT1 polymerizes CCA at the 3' end of pre-tRNA
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authored
[InstanceEdit:5696808] May, Bruce, 2015-05-29
catalystActivity
[CatalystActivity:5696806] 5'-3' RNA polymerase activity of TRNT1 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5696805] May, Bruce, 2015-05-30
dbId
5696807
displayName
TRNT1 polymerizes CCA at the 3' end of pre-tRNA
edited
[InstanceEdit:5696808] May, Bruce, 2015-05-29
eventOf
[Pathway:R-HSA-6784531] tRNA processing in the nucleus - Homo sapiens
followingEvent
[Reaction:R-HSA-6785438] NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) - Homo sapiens
[Reaction:R-HSA-6782416] TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) - Homo sapiens
[Reaction:R-HSA-6782419] TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) - Homo sapiens
[Reaction:R-HSA-6786583] PUS7 isomerizes uridine to pseudouridine in tRNAs - Homo sapiens
[Reaction:R-HSA-6782286] METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 - Homo sapiens
[Reaction:R-HSA-6782336] ADAT1 deaminates adenosine-37 in tRNA(Ala) - Homo sapiens
[Reaction:R-HSA-6785409] NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) - Homo sapiens
[Reaction:R-HSA-6783492] TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) - Homo sapiens
[Reaction:R-HSA-6786621] TRMT10A methylates guanosine-9 in tRNA - Homo sapiens
[Reaction:R-HSA-8870289] PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA - Homo sapiens
[Reaction:R-HSA-8932765] NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) - Homo sapiens
[Reaction:R-HSA-6782388] NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) - Homo sapiens
[Reaction:R-HSA-6782381] PUS1 isoform 2 isomerizes uridine residues to pseudouridine residues in the anticodon stems of tRNAs - Homo sapiens
[Reaction:R-HSA-6784494] KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs - Homo sapiens
[Reaction:R-HSA-5696813] TSEN complex cleaves the intron from pre-tRNA - Homo sapiens
[Reaction:R-HSA-6785478] Processed tRNA binds XPOT and RAN:GTP - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:77784] tRNA 3'-end processing
input
[DefinedSet:R-HSA-6784544] 5',3' cleaved pre-tRNA [nucleoplasm]
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
2 ×
[SimpleEntity:R-ALL-29470] CTP [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5696716] A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair
[LiteratureReference:5696715] Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization
[LiteratureReference:5696694] On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme
[LiteratureReference:5696759] Domain movements during CCA-addition: A new function for motif C in the catalytic core of the human tRNA nucleotidyltransferases
[LiteratureReference:5696691] A splice variant of the human CCA-adding enzyme with modified activity
[LiteratureReference:6784561] A eubacterial origin for the human tRNA nucleotidyltransferase?
[LiteratureReference:6790484] Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
TRNT1 polymerizes CCA at the 3' end of pre-tRNA
output
[DefinedSet:R-HSA-6784557] Cleaved tRNA with 3' CCA [nucleoplasm]
3 ×
[SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent
[Reaction:R-HSA-5696815] ELAC2 cleaves the 3' end of pre-tRNA - Homo sapiens
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:6790491] Levinger, Louis, 2015-08-10
[InstanceEdit:6792690] Motorin, Yuri, 2015-08-25
[InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5696807
summation
[Summation:6784577] TRNT1 (CCA-adding enzyme) polymerizes the non-templated nucl...
Referrals
(precedingEvent)
[Reaction:R-HSA-6785438] NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)
[Reaction:R-HSA-6782416] TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)
[Reaction:R-HSA-6782419] TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)
[Reaction:R-HSA-6786583] PUS7 isomerizes uridine to pseudouridine in tRNAs
[Reaction:R-HSA-6782286] METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46
[Reaction:R-HSA-6782336] ADAT1 deaminates adenosine-37 in tRNA(Ala)
[Reaction:R-HSA-6785409] NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)
[Reaction:R-HSA-6783492] TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)
[Reaction:R-HSA-6786621] TRMT10A methylates guanosine-9 in tRNA
[Reaction:R-HSA-8870289] PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA
[Reaction:R-HSA-8932765] NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)
[Reaction:R-HSA-6782388] NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)
[Reaction:R-HSA-6782381] PUS1 isoform 2 isomerizes uridine residues to pseudouridine residues in the anticodon stems of tRNAs
[Reaction:R-HSA-6784494] KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs
[Reaction:R-HSA-5696813] TSEN complex cleaves the intron from pre-tRNA
[Reaction:R-HSA-6785478] Processed tRNA binds XPOT and RAN:GTP
(hasEvent)
[Pathway:R-HSA-6784531] tRNA processing in the nucleus
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