Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER

Stable Identifier
Homo sapiens
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ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds to the pre-incision complex at the transcription-coupled nucleotide excision repair (TC-NER) site to form the incision complex. Binding of ERCC5 (XPG) to the NER site precedes the recruitment of ERCC1:ERCC4 (Riedl et al. 2003). ERCC1 directly interacts with the XPA, and this interaction is necessary for the loading of ERCC1:ERCC4 to the open bubble structure in damaged dsDNA and the progression of TC-NER (Tsodikov et al. 2007, Orelli et al. 2010).

Literature References
PubMed ID Title Journal Year
19940136 The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways

McClendon, TB, Orelli, B, Niedernhofer, LJ, Ellenberger, T, Schärer, OD, Tsodikov, OV

J. Biol. Chem. 2010
14517266 The comings and goings of nucleotide excision repair factors on damaged DNA

Riedl, T, Egly, JM, Hanaoka, F

EMBO J. 2003
17948053 Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

Orelli, B, Shoshani, I, Wagner, G, Oberman, R, Ellenberger, T, Ivanov, D, Staresincic, L, Schärer, OD, Tsodikov, OV

EMBO J. 2007
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