Reactome | USP13 deubiquitinates BECN1,USP10

USP13 deubiquitinates BECN1,USP10

Stable Identifier

R-HSA-6781779

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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USP13 preferentially cleaves Lys-63-linked polyubiquitin chains (Zhang et al. 2011). It mediates deubiquitination of BECN1, a key regulator of autophagy, which stabilizes PIK3C3/VPS34-containing complexes. USP13 can deubiquitinate USP10, an essential regulator of TP53 stability (Liu et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21962518	Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13 Xia, H, Choi, A, Ma, D, Zhang, L, Norberg, HV, Zhu, Z, Kim, M, Zhang, T, Jin, M, Xu, L, Cai, Y, Liu, J, Ke, H, Yu, J, Furuya, T, Hao, Y, Wang, H, Yuan, J, Li, Y, Li, Y	Cell	2011
22216260	Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin Zhou, CJ, Song, AX, Zhang, YH, Zhou, ZR, Hu, HY	PLoS ONE	2011