USP13 deubiquitinates BECN1,USP10

Stable Identifier
R-HSA-6781779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP13 preferentially cleaves Lys-63-linked polyubiquitin chains (Zhang et al. 2011). It mediates deubiquitination of BECN1, a key regulator of autophagy, which stabilizes PIK3C3/VPS34-containing complexes. USP13 can deubiquitinate USP10, an essential regulator of TP53 stability (Liu et al. 2011).

Literature References
PubMed ID Title Journal Year
22216260 Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin

Zhang, YH, Zhou, CJ, Zhou, ZR, Song, AX, Hu, HY

PLoS ONE 2011
21962518 Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

Liu, J, Xia, H, Kim, M, Xu, L, Li, Y, Zhang, L, Cai, Y, Norberg, HV, Zhang, T, Furuya, T, Jin, M, Zhu, Z, Wang, H, Yu, J, Li, Y, Hao, Y, Choi, A, Ke, H, Ma, D, Yuan, J

Cell 2011
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP13:K63polyUb-BECN1,K63polyUb-USP10 [cytosol]

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