USP13 deubiquitinates BECN1,USP10

Stable Identifier
R-HSA-6781779
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP13 preferentially cleaves Lys-63-linked polyubiquitin chains (Zhang et al. 2011). It mediates deubiquitination of BECN1, a key regulator of autophagy, which stabilizes PIK3C3/VPS34-containing complexes. USP13 can deubiquitinate USP10, an essential regulator of TP53 stability (Liu et al. 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP13:K63polyUb-BECN1,K63polyUb-USP10 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed