Reactome | USP15 is a ubiquitin-specific protease (Baker et al. 1999) r...

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created	[InstanceEdit:6781793] Jupe, Steve, 2015-06-02
dbId	6781761
displayName	USP15 is a ubiquitin-specific protease (Baker et al. 1999) r...
literatureReference	[LiteratureReference:6781781] Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases [LiteratureReference:6781806] USP15 is a deubiquitylating enzyme for receptor-activated SMADs [LiteratureReference:2179322] USP15 stabilizes TGF-? receptor I and promotes oncogenesis through the activation of TGF-? signaling in glioblastoma [LiteratureReference:6781810] USP15 negatively regulates Nrf2 through deubiquitination of Keap1
modified	[InstanceEdit:8856270] Jupe, Steve, 2016-02-09
schemaClass	Summation
text	USP15 is a ubiquitin-specific protease (Baker et al. 1999) reported to act on several substrates. It promotes deubiquitination of monoubiquitinated R-SMADs, indirectly promoting the activation of TGF-beta target genes (Inui et al. 2011). USP15 binds the SMAD7:SMURF2 complex, deubiquitinating and stabilizing the type I TGFBeta receptor (TGFBR1), leading to enhanced TGF-Beta signalling (Eichorn et al. 2012). USP15 deubiquitinates KEAP1, which suppresses the Nrf2 pathway (Villeneuve et al. 2013).

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