Reactome | PRKCA [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10267475] calcium,diacylglycerol-dependent serine/threonine kinase activity of PRKCA [cytosol] [CatalystActivity:10253961] diacylglycerol binding activity of PRKCA [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-422275] Protein Kinase C, alpha type: DAG [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-400015] Diacylgycerol activates Protein kinase C, alpha type - Canis familiaris [Reaction:R-CFA-1433508] PKC alpha interacts with and phosphorylates KIT - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10234177
displayName	PRKCA [cytosol]
endCoordinate	672
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-58196] PRKCA [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-CFA-114528] Protein Kinase C, conventional [cytosol] - Canis familiaris [DefinedSet:R-CFA-8855913] RET interactors [cytosol] - Canis familiaris
name	PRKCA A0A8I3PUQ8
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3PUQ8] UniProt:A0A8I3PUQ8
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-58196
startCoordinate	2

(activeUnit)	[CatalystActivity:10253947] protein serine/threonine kinase activity of Protein Kinase C, alpha type: DAG [plasma membrane]
(hasMember)	[DefinedSet:R-CFA-114528] Protein Kinase C, conventional [cytosol] [DefinedSet:R-CFA-8855913] RET interactors [cytosol] [DefinedSet:R-CFA-5218761] PKCA,PKCB,PKCD,PKCZ [cytosol] [DefinedSet:R-CFA-112001] Protein kinase C (alpha, gamma, delta) [cytosol]
(input)	[Reaction:R-CFA-1433508] PKC alpha interacts with and phosphorylates KIT [Reaction:R-CFA-400015] Diacylgycerol activates Protein kinase C, alpha type
(physicalEntity)	[CatalystActivity:10267475] calcium,diacylglycerol-dependent serine/threonine kinase activity of PRKCA [cytosol] [CatalystActivity:10253961] diacylglycerol binding activity of PRKCA [cytosol]
(hasComponent)	[Complex:R-CFA-422275] Protein Kinase C, alpha type: DAG [plasma membrane] [Complex:R-CFA-1433473] p-KIT (S741,746):PKC alpha [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-58196] PRKCA [cytosol]