USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1

Stable Identifier
Reaction [transition]
Homo sapiens
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USP17 regulates cell proliferation by deubiquitinating and inhibiting RCE1, which influences the localization and activation of the small GTPases NRAS and HRAS (Burrows et al. 2009). In addition, USP17 mediates deubiquitination of CDC25A, which prevents CDC25A degradation by the proteasome during the G1/S and G2/M phases, promoting cell-cycle progression (Pereq et al. 2010). USP17 cleaves Lys-48 and Lys-63-linked polyubiquitin chains from the cytoplasmic innate immune receptors DDX58 (RIG-I) and IFIH1 (MDA5), which increases activation of the IFN-beta promoter, part of the cellular response to viral infection (Chen et al. 2010). USP17 expression is upregulated by interleukin-4 and interleukin-6 (Burrows et al. 2004).
Literature References
PubMed ID Title Journal Year
20368735 The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling

Shu, HB, Liu, Y, Tan, B, Chen, R, Zhang, L, Zhong, B

Cell Res. 2010
19188362 USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity

McFarlane, C, Scott, CJ, De la Vega, M, Johnston, JA, McGrattan, MJ, Kelvin, AA, Burden, RE, Govender, U, Dib, K, Quinn, DJ, Burrows, JF, Gadina, M

J. Biol. Chem. 2009
20228808 Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

O'Rourke, KM, Pereg, Y, Komuves, L, French, DM, Dey, A, Liu, BY, Sagolla, M, Dixit, VM

Nat. Cell Biol. 2010
Catalyst Activity

cysteine-type deubiquitinase activity of USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol]

Orthologous Events
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